Serving Downtown Cleveland, via the Detroit-Superior Bridge and the W 25 Corridor, and locations in:
- Stronsgville via the Strongsville Park-N-Ride (51);
- Parma and the Parma Transit Center (51A);
- Broadview Heights and the MetroHealth Brecksville Health and Surgery Center (51B);
- Garfield Commons (51C).
Incorporates service formerly offered by route 20: W. 25 - State and route 35: W. 25 - Broadview. The Downtown layover for all trips is at E 12 & Rockwell (weekdays) or Superior & W 3 (evenings & weekends).
On Sept. 21, 2017, RTA announced a new partnership with the MetroHealth System to rebrand the number 51 family of routes. Beginning Dec. 3, 2017, the rebranded MetroHealth Line will offer commuters an upgraded ride on 20 new, specially designed vehicles, fully branded with the MetroHealth logo. More than 400 bus stop signs and 37 shelters will also display the new logo along the routes.
The 51-A, 51-B and 51-C operate more than 200 bus trips per day and link the MetroHealth campus with both Downtown Cleveland to the north and the neighborhoods and suburbs to the south.
MetroHealth has five health-care facilities along the route.
51: 7 Days a Week, Early AM thru Evening
51A: Parma Transit Center, 7 Days a Week, Early AM thru Late Night
51A: Brookpark, 7 Days a Week, 24 Hours a Day
51B: 7 Days a Week, Early AM thru Late Night
51C: 7 Days a Week, Early AM thru Evening