Serving Downtown Cleveland, via the Detroit-Superior Bridge and the W 25 corridor, and locations in:
- Stronsgville via the Strongsville Park-N-Ride (51);
- Parma and the Parma Transit Center (51A);
- Broadview Heights and the MetroHealth Brecksville Health and Surgery Center (51B);
- Garfield Commons (51C).
Incorporates service formerly offered by route 20: W. 25 - State and route 35: W. 25 - Broadview. The downtown layover for all trips is at E 12 & Rockwell (weekdays) or Superior & W 3 (evenings & weekends).